Ketamine is a drug that is used commonly in hospitals as pain suppressors and anesthesia for surgical procedures. In the recent years, it has become a viable alternative for the treatment of a range of conditions such as migraines, anxiety, OCD, and PTSD. In controlled doses, ketamine can be used to provide pain relief, but in high doses, it can lead to hallucinations and “out of body” experiences.
If you are looking to try ketamine infusions, then you can visit the website of Mind Peace clinic. They provide their customers with quality ketamine infusions for the treatment of PTSD, anxiety, depression, and other chronic pain syndromes. You can learn about ketamine and the way it functions on its website https://mindpeaceclinic.com/what-is-ketamine/. They have clinics situated in different US cities such as Arlington, Norfolk, and Richmond where you can book an appointment.
How does Ketamine work?
Ketamine works by interacting with the NMDA receptor and blocking it to stop the brain from forming connections normally. The antidepressant effects work by activating the mTor molecule of the cell through the AMPA receptor.
This releases G proteins that make nerve cells grow extra dendritic spines and increase the production of glutamate. Furthermore, ketamine also decreases nitric oxide production and networks with opioid receptors that reduce pain sensations.
Effects of ketamine on human body
- Nausea and vomiting in rare cases, depending on the dosage of ketamine.
- Cardiovascular changes such as increased blood pressure and heart rate.
- Bronchodilation or increase in the airflow to the lungs.
What is CRPS?
CRPS or chronic regional pain syndrome is extreme pain and sensitivity of small stimuli usually in the legs and arms. It can often be a result of an injury such as fracture, sprain or a small surgery. The pain of CRPS is often misdiagnosed or not detected. If you have at least 2 or 3 of the following symptoms, then you can be diagnosed with CRPS.
- Changes in skin color
- Changes in nail and hair growth
- Limitation in movement
- Skin swelling
The doctors first try to relieve the pain through prescription pain relievers. Other traditional methods to cure CRPS are nerve blocks, neuromodulation in which electrical stimulation is used to reduce nerve firing and relieve pain, and physical therapy.
Relationship between ketamine and CRPS
CRPS is caused by changes in the central nervous system which causes pain in the body. Even a small pain from a bump in the leg can be amplified into severe pain. This occurs due to the activation of the nerve receptor named the NMDA receptor.
Ketamine is an anesthetic that blocks these receptors which will ultimately decrease the pain. Ketamine is not completely proven to be a harmless cure for CRPS, so it is only used as a last resort.
Ketamine can be inserted into the body through an intravenous line (IV) into the blood vessels. Estimates of 50 to 60 percent of patients who undergo ketamine transfusion feel relief immediately. The effects may last from one month up to a year.
Ketamine has not been FDA-approved, but with ongoing research, it could be a cure for CRPS of other chronic pain.